I’ll give you my experience and advice regarding CIEMs vs UIEMs, no problem. As far as sound changed from universal to custom goes that really depends on the individual IEM. There are some general changes that tend to apply across the board though. So, in general, CIEMs will fit more comfortably, isloate better, seal better, and cause fewer problems with fatigue/pain from wearing them over long sessions. This is all assuming they’re well made from proper scans. Problems regarding poorly done scans and poorly made CIEMs are much rarer than they used to be because of the increase in the accuracy of ear scan technology and the better tech used to make CIEMs these days.
Now, with individual models you can get some pretty significant changes from the universal versions though many manufacturers do their best to measure the IEMs and compensate as needed so that the universal and custom versions are as close to identical as possible. It’s common for the CIEM version to pick up a bit of bass extension and punch (likely from deeper/better fit and better seal) and low level detail and microdynamics often become clearer and easier to hear most likely for the same reason(s). When going to CIEMs from a UIEM when a bone conduction driver is involved the changes can be much more noticeable and significant depending on how the BC driver is implemented because it is brought into much closer proximity/contact with the inner ear and thus is able to function more effectively. I have found that DD or Hybrid CIEMs tend to exhibit lesser differences than their all BA counterparts. I have also found that the closer fit on CIEMs can sometimes change how closely bass ports/holes are to the ear which can also have significant effects, increasing bass quanitity. Last, but not least, IEM designs that employ tuning tubes that go directly from the nozzle to the driver(s) also tend to be effected less by changing to a custom fit than IEMs that are designed with acoustic chambers or open inner shell topologies (for example coaxial designs, BAs in the nozzle w/ DDs secured the the shell behind, etc).
I think that covers my observations that apply generally as best I can so now we come to advice. This may seem obvious, but I wouldn’t go with a CIEM over a UIEM if you have any desire to resell and are wanting to recoup funds. Reselling CIEMs is hard and they only fetch a fraction of the MSRP because the buyer has to go through the trouble and expense of having them reshelled to fit. So basically, I would stick to UIEMs unless you’re purchasing a pair that you know you will like and be keeping long term or if recouping the money in resale is not important to you and you’re fine with taking a big loss or possibly not being able to resell at all. Also important to note, CIEMs actually require a bit more maintenance as far as cleaning goes than UIEMs. I clean all my IEMs regualrly regardless, but CIEMs really need to be cleaned after pretty much an extended use and stored in a dry area and/or with descant packs. This needs to be done preventatively because it’s much harder to try to get gunk and blockages out of your CIEM after it has built up than it is with your average universal and it’s often not cheap to have to pay the manufacturer to crack it open for cleaning and repair if something goes wrong because you didn’t take proper care of your CIEMs. Lastly, if you have a pair of CIEMs that you’re keeping for a period of years, be aware that your ears and, most importantly, your ear canals change shape over time so you may eventually need to have the CIEM reshelled. For example, I have had my 64Audio A18s for a little over three years and I was still totally comfortable with them, but when I got new scans done for a pair of A12t I was having made, my audiologist happened to mention that there was a noticeable change in the inner angle of my right ear canal (I have jaw problems from an old injury so mine probably change faster than average, but everyone’s change according to my doc). After hearing that I decided to have the A18s reshelled using my new scans even though I hadn’t noticed an trouble with them just to see how big the difference was. When I got them back and popped them in, I did notice a deeper fit, slightly better isolation, and that it was easier to get the IEM seated. I never noticed any issues due to the slow changes over the course of years and likely wouldn’t have for even longer, but my point in bringing it up is that eventually CIEMs will need to change with you so it’s something to think about though most companies I have worked with will reshell their own CIEMs at very reasonable prices, often way less than their everyday CIEM reshelling fee they charge.
Anyways, if you, @Ohmboy , or anyone else have any specific questions, about something I didn’t cover feel free to ask and I’ll do my best to answer. I hope this was helpful! 

P.S. Sorry for any typos. Typed this on my phone while riding in a moving vehicle with my big caveman thumbs. 
Edit: Finally fixed what seemed like a million typos so that any future readers might actually think they’re reading useful experiences/advice rather than the musings of an illiterate child. 